Article
New selective amplifier genes containing c-Mpl for hematopoietic cell expansion.
Biochemical and biophysical research communications - 28 Mar 2003
Nagashima Takeyuki, Ueda Yasuji, Hanazono Yutaka, Kume Akihiro, Shibata Hiroaki, Ageyama Naohide, Terao Keiji, Ozawa Keiya, Hasegawa Mamoru
Abstract excerpt
We previously developed "selective amplifier genes (SAGs)" which confer a growth advantage to transduced cells. The SAG is a chimeric gene encoding the G-CSF receptor (GCR) and the estrogen or tamoxifen (Tm) receptor and is able to expand transduced hematopoietic cells by treatment with estrogen...
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