Article
Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease.
JAMA - 7 Mar 2017
Khera Amit V, Won Hong-Hee, Peloso Gina M, O'Dushlaine Colm, Liu Dajiang, Stitziel Nathan O, Natarajan Pradeep, Nomura Akihiro, Emdin Connor A, Gupta Namrata, Borecki Ingrid B, Asselta Rosanna, Duga Stefano, Merlini Piera Angelica, Correa Adolfo, Kessler Thorsten, Wilson James G, Bown Matthew J, Hall Alistair S, Braund Peter S, Carey David J, Murray Michael F, Kirchner H Lester, Leader Joseph B, Lavage Daniel R, Manus J Neil, Hartzel Dustin N, Samani Nilesh J, Schunkert Heribert, Marrugat Jaume, Elosua Roberto, McPherson Ruth, Farrall Martin, Watkins Hugh, Lander Eric S, Rader Daniel J, Danesh John, Ardissino Diego, Gabriel Stacey, Willer Cristen, Abecasis Gonçalo R, Saleheen Danish, Dewey Frederick E, Kathiresan Sekar
Abstract excerpt
Importance: The activity of lipoprotein lipase (LPL) is the rate-determining step in clearing triglyceride-rich lipoproteins from the circulation. Mutations that damage the LPL gene (LPL) lead to lifelong deficiency in enzymatic activity and can provide insight into the relationship of LPL to human disease. Objective: To determine whether rare and/or common variants in LPL are associated with early-onset coronary...
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