Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of LIPA gene polymorphisms with obesity-related metabolic complications among severely obese patients.

Obesity (Silver Spring, Md.) - 1 Oct 2012

Guénard Frédéric, Houde Alain, Bouchard Luigi, Tchernof André, Deshaies Yves, Biron Simon, Lescelleur Odette, Biertho Laurent, Marceau Simon, Pérusse Louis, Vohl Marie-Claude

Abstract excerpt

The lipase A, lysosomal acid, cholesterol esterase enzyme (LIPA) is involved in the hydrolysis of triglycerides (TGs) and cholesteryl esters (CEs) delivered to lysosomes. LIPA deficiency in human causes two distinct phenotypes characterized by intracellular storage of CE and derangements in the control of cholesterol production, namely the Wolman disease (WD) and the CE storage disease (CESD). To test the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Triglycerides
Share to Cardiovascular Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Metabolic Syndrome

Share to Obesity, Morbid

Share to Quebec

Share to Sequence Analysis, DNA

Share to Sterol Esterase

Source

Identifiers

PMID: 22395809
DOI: 10.1038/oby.2012.52

Genes

LIPA
DBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of LIPA gene polymorphisms with obesity-related metabolic complications among severely obese patients.PMID 22395809Read ↗

Identification and metabolic profiling of patients with lysosomal acid lipase deficiency.Semantic proximity Read ↗

LIPA gene mutations affect the composition of lipoproteins: Enrichment in ACAT-derived cholesteryl esters.Semantic proximity Read ↗

Frequency of rs1051338 and rs116928232 Variants in Individuals from Northwest Mexico.Semantic proximity Read ↗

Hepatic lipase (LIPC) sequencing in individuals with extremely high and low high-density lipoprotein cholesterol levels.Semantic proximity Read ↗

Implications of central obesity-related variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on quantitative metabolic traits in adult Danes.Semantic proximity Read ↗

Lysosomal lipase deficiency: molecular characterization of eleven patients with Wolman or cholesteryl ester storage disease.Semantic proximity Read ↗

First LIPA Mutational Analysis in Egyptian Patients Reveals One Novel Variant: Wolman Disease.Semantic proximity Read ↗

Lysosomal acid lipase deficiency: A hidden disease among cohorts of familial hypercholesterolemia?Semantic proximity Read ↗

Lipoprotein lipase gene sequencing and plasma lipid profile.Semantic proximity Read ↗

Effect of a common missense variant in LIPA gene on fatty liver disease and lipid phenotype: New perspectives from a single-center observational study.Semantic proximity Read ↗

Genetic Variants in Severe Hypertriglyceridemia Among Taiwanese Participants - Insights From Genome-Wide Association and Whole-Exome Sequencing Analyses.Semantic proximity Read ↗

A functional variant in the exon 5 of PLIN1 reduces risk of central obesity by possible regulation of lipid storage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.