Regulatory variation within and between species.

doi:10.1146/annurev-genom-082908-150139

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Article

Regulatory variation within and between species.

Annual review of genomics and human genetics - 1 Jan 2011

Zheng Wei, Gianoulis Tara A, Karczewski Konrad J, Zhao Hongyu, Snyder Michael

Abstract excerpt

Understanding how individuals differ from one another and from closely related species is a fundamental problem in biology. Recent evidence suggests that much of the variation both within and between species is due to differential gene regulation. Here we review differential gene regulation focusing on evolutionary-developmental (evo-devo) biology, global comparison of genomic sequences, whole-genome gene...

Topics

Animals
Biological Evolution
Evolution, Molecular
Gene Expression Regulation
Genetic Variation
Humans
Transcription Factors

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Open in PubMed

Identifiers

PMID: 21721942
DOI: 10.1146/annurev-genom-082908-150139

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