Article
Structure of the Transcriptional Regulatory Network Correlates with Regulatory Divergence in Drosophila.
Molecular biology and evolution - 1 Jun 2017
Yang Bing, Wittkopp Patricia J
Abstract excerpt
Transcriptional control of gene expression is regulated by biochemical interactions between cis-regulatory DNA sequences and trans-acting factors that form complex regulatory networks. Genetic changes affecting both cis- and trans-acting sequences in these networks have been shown to alter patterns of gene expression as well as higher-order organismal phenotypes. Here, we investigate how the structure of these...
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