Article
Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study.
BMC medical genetics - 25 Sept 2013
Fesinmeyer Megan D, Meigs James B, North Kari E, Schumacher Fredrick R, Bůžková Petra, Franceschini Nora, Haessler Jeffrey, Goodloe Robert, Spencer Kylee L, Voruganti Venkata Saroja, Howard Barbara V, Jackson Rebecca, Kolonel Laurence N, Liu Simin, Manson JoAnn E, Monroe Kristine R, Mukamal Kenneth, Dilks Holli H, Pendergrass Sarah A, Nato Andrew, Wan Peggy, Wilkens Lynne R, Le Marchand Loic, Ambite José Luis, Buyske Steven, Florez Jose C, Crawford Dana C, Hindorff Lucia A, Haiman Christopher A, Peters Ulrike, Pankow James S
Abstract excerpt
BACKGROUND: Multiple genome-wide association studies (GWAS) within European populations have implicated common genetic variants associated with insulin and glucose concentrations. In contrast, few studies have been conducted within minority groups, which carry the highest burden of impaired glucose homeostasis and type 2 diabetes in the U.S. METHODS: As part of the 'Population Architecture using Genomics and...
Topics
- Adaptor Proteins, Signal Transducing
- Adult
- Black or African American
- Aged
- Alleles
- Asian People
- Blood Glucose