Article
A novel bayesian graphical model for genome-wide multi-SNP association mapping.
Genetic epidemiology - 1 Jan 2012
Zhang Yu
Abstract excerpt
Most disease association mapping algorithms are based on hypothesis testing procedures that test one variant at a time. Those methods lose power when the disease mutations are jointly tagged by multiple variants, or when gene-gene interaction exist. Nearby variants are also correlated, for which procedures ignoring the dependence between variants will inevitably produce redundant results. With a large number of...
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