Article
Novel association strategy with copy number variation for identifying new risk Loci of human diseases.
PloS one - 20 Aug 2010
Chen Xianfeng, Li Xinlei, Wang Ping, Liu Yang, Zhang Zhenguo, Zhao Guoping, Xu Haiming, Zhu Jun, Qin Xueying, Chen Suchao, Hu Landian, Kong Xiangyin
Abstract excerpt
BACKGROUND: Copy number variations (CNV) are important causal genetic variations for human disease; however, the lack of a statistical model has impeded the systematic testing of CNVs associated with disease in large-scale cohort. METHODOLOGY/PRINCIPAL FINDINGS: Here, we developed a novel integrated strategy to test CNV-association in genome-wide case-control studies. We converted the single-nucleotide...
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