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Article

Multiple SNP Set Analysis for Genome-Wide Association Studies Through Bayesian Latent Variable Selection.

Genetic epidemiology - 1 Dec 2015

Lu Zhao-Hua, Zhu Hongtu, Knickmeyer Rebecca C, Sullivan Patrick F, Williams Stephanie N, Zou Fei

Abstract excerpt

The power of genome-wide association studies (GWAS) for mapping complex traits with single-SNP analysis (where SNP is single-nucleotide polymorphism) may be undermined by modest SNP effect sizes, unobserved causal SNPs, correlation among adjacent SNPs, and SNP-SNP interactions. Alternative approaches for testing the association between a single SNP set and individual phenotypes have been shown to be promising for...

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PMID: 26515609
DOI: 10.1002/gepi.21932
PMCID: PMC4715655

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