Article
Hidden Markov models for controlling false discovery rate in genome-wide association analysis.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012
Wei Zhi
Abstract excerpt
Genome-wide association studies (GWAS) have shown notable success in identifying susceptibility genetic variants of common and complex diseases. To date, the analytical methods of published GWAS have largely been limited to single single nucleotide polymorphism (SNP) or SNP-SNP pair analysis, coupled with multiplicity control using the Bonferroni procedure to control family wise error rate (FWER). However, since...
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