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Article

Establishment and characterization of a novel dedifferentiated chondrosarcoma cell line, SMU-DDCS, harboring an IDH1 mutation.

Human cell - 1 Nov 2023

Emori Makoto, Nakahashi Naoya, Takasawa Akira, Murata Kenji, Murahashi Yasutaka, Shimizu Junya, Tsukahara Tomohide, Sugita Shintaro, Takada Kohichi, Hasegawa Tadashi, Osanai Makoto, Iba Kosuke

Abstract excerpt

Dedifferentiated chondrosarcoma (DDCS) is a high-grade subtype with a bi-morphic histological appearance of a conventional chondrosarcoma component and it can abruptly transition to a high-grade non-cartilaginous sarcoma. To better understand the biological features of DDCSs and to help develop new therapies, a novel DDCS cell line, SMU-DDCS, was established. Tissue from an open biopsy of a tumor resected from a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 37454032
DOI: 10.1007/s13577-023-00944-0

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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