Article
Distinct IDH1/2-associated Methylation Profile and Enrichment of TP53 and TERT Mutations Distinguish Dedifferentiated Chondrosarcoma from Conventional Chondrosarcoma.
Cancer research communications - 1 Mar 2023
Dermawan Josephine Kam Tai, Nafa Khedoujia, Mohanty Abhinita, Xu Yingjuan, Rijo Ivelise, Casanova Jacklyn, Villafania Liliana, Benhamida Jamal, Kelly Ciara M, Tap William D, Boland Patrick J, Fabbri Nicola, Healey John H, Ladanyi Marc, Lu Chao, Hameed Meera
Abstract excerpt
Dedifferentiated chondrosarcoma (DDCS) is a rare high-grade chondrosarcoma characterized by a well-differentiated chondrosarcoma (WDCS) component that abruptly transitions to a high-grade, noncartilaginous sarcomatous component. To date, the molecular pathogenesis of DDCS and its distinction from conventional chondrosarcoma remain poorly understood. By targeted sequencing, we examined the mutational and...
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