Article
Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines.
Oncotarget - 20 May 2015
Suijker Johnny, Oosting Jan, Koornneef Annemarie, Struys Eduard A, Salomons Gajja S, Schaap Frank G, Waaijer Cathelijn J F, Wijers-Koster Pauline M, Briaire-de Bruijn Inge H, Haazen Lizette, Riester Scott M, Dudakovic Amel, Danen Erik, Cleton-Jansen Anne-Marie, van Wijnen Andre J, Bovée Judith V M G
Abstract excerpt
Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are found in a subset of benign and malignant cartilage tumors, gliomas and leukaemias. The mutant enzyme causes the production of D-2-hydroxyglutarate (D-2-HG), affecting CpG island and histone methylation. While mutations in IDH1/2 are early events in benign cartilage tumors, we evaluated whether these mutations play a role in malignant chondrosarcomas....
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