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Article

Presence of IDH2 and TP53 mutations significantly reduces survival of patients with chondrosarcoma.

Cancer - 1 Apr 2026

Weidlich Anne, Schaser Klaus-Dieter, Juratli Tareq A, Pablik Jessica, Märdian Sven, Hauptmann Kathrin, Schwabe Philipp, Richter Stephan, Fritzsche Hagen

Abstract excerpt

BACKGROUND: Chondrosarcoma (CS) has a prognosis largely influenced by tumor grade. Although IDH mutations have been reported in CS, impact on patient`s survival remains controversial. This study aims to assess prognostic relevance of IDH mutations on disease-specific survival (DSS), metastasis-free survival (MFS), and local recurrence-free survival (RFS), in a large cohort of CS patients. METHODS: The authors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41906217
DOI: 10.1002/cncr.70376
PMCID: PMC13033615

Genes

IDH2
CS
TP53
IDH1
CDKN2A
TERT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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Presence of IDH2 and TP53 mutations significantly reduces survival of patients with chondrosarcoma.PMID 41906217Read ↗

Clinico-Genomic Profiling of Conventional and Dedifferentiated Chondrosarcomas Reveals TP53 Mutation to Be Associated with Worse Outcomes.Semantic proximity Read ↗

Genomic Profiling Identifies Association of IDH1/IDH2 Mutation with Longer Relapse-Free and Metastasis-Free Survival in High-Grade ChondrosarcomaSemantic proximity Read ↗

Prognostic importance of IDH mutations in chondrosarcoma: An individual patient data meta-analysis.Semantic proximity Read ↗

Distinct IDH1/2-associated Methylation Profile and Enrichment of TP53 and TERT Mutations Distinguish Dedifferentiated Chondrosarcoma from Conventional Chondrosarcoma.Semantic proximity Read ↗

IDH1/2 Mutations Predict Shorter Survival in ChondrosarcomaSemantic proximity Read ↗

Biological Heterogeneity of Chondrosarcoma: From (Epi) Genetics through Stemness and Deregulated Signaling to ImmunophenotypeSemantic proximity Read ↗

Genomic Characterization of Chondrosarcoma Reveals Potential Therapeutic TargetsSemantic proximity Read ↗

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A genetic model for central chondrosarcoma evolution correlates with patient outcome.Semantic proximity Read ↗

Is the IDH Mutation a Good Target for Chondrosarcoma Treatment?Semantic proximity Read ↗

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