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Article

Beyond RNA-binding domains: determinants of protein-RNA binding.

RNA (New York, N.Y.) - 18 Nov 2024

Zigdon Inbal, Carmi Miri, Brodsky Sagie, Rosenwaser Zohar, Barkai Naama, Jonas Felix

Abstract excerpt

RNA-binding proteins (RBPs) are composed of RNA-binding domains (RBDs) often linked via intrinsically disordered regions (IDRs). Structural and biochemical analyses have shown that disordered linkers contribute to RNA binding by orienting the adjacent RBDs and also characterized certain disordered repeats that directly contact the RNA. However, the relative contribution of IDRs and predicted RBDs to the in vivo...

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Identifiers

PMID: 39353735
DOI: 10.1261/rna.080026.124
PMCID: PMC11571813

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