Article
How the dynamics of the metal-binding loop region controls the acid transition in cupredoxins.
Biochemistry - 22 Oct 2013
Paltrinieri Licia, Borsari Marco, Battistuzzi Gianantonio, Sola Marco, Dennison Christopher, de Groot Bert L, Corni Stefano, Bortolotti Carlo Augusto
Abstract excerpt
Many reduced cupredoxins undergo a pH-dependent structural rearrangement, triggered by protonation of the His ligand belonging to the C-terminal hydrophobic loop, usually termed the acid transition. At variance with several members of the cupredoxin family, the acid transition is not observed for azurin (AZ). We have addressed this issue by performing molecular dynamics simulations of AZ and four mutants, in...
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