Structural Basis for the Effects of Phenylalanine on Tuning the Reduction Potential of Type 1 Copper in Azurin.

doi:10.1021/acs.inorgchem.3c01365

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Article

Structural Basis for the Effects of Phenylalanine on Tuning the Reduction Potential of Type 1 Copper in Azurin.

Inorganic chemistry - 24 Jul 2023

Liu Yiwei, Marshall Nicholas M, Yu Sheng-Song, Kim Wantae, Gao Yi-Gui, Robinson Howard, Nilges Mark J, Zhang Yan, New Siu Yee, Lu Yi

Abstract excerpt

In order to investigate the effects of the secondary coordination sphere in fine-tuning redox potentials (E°') of type 1 blue copper (T1Cu) in cupredoxins, we have introduced M13F, M44F, and G116F mutations both individually and in combination in the secondary coordination sphere of the T1Cu center of azurin (Az) from Pseudomonas aeruginosa. These variants were found to differentially influence the E°' of T1Cu,...

Topics

Azurin
Copper
Phenylalanine
Models, Molecular
Mutation
Oxidation-Reduction
Pseudomonas aeruginosa

Source

Open in PubMed

Identifiers

PMID: 37424080
DOI: 10.1021/acs.inorgchem.3c01365

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