Article
Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin.
Cardiovascular diabetology - 24 Sept 2013
Mansor Latt S, Gonzalez Eileen R, Cole Mark A, Tyler Damian J, Beeson Jessica H, Clarke Kieran, Carr Carolyn A, Heather Lisa C
Abstract excerpt
BACKGROUND: To study the pathogenesis of diabetic cardiomyopathy, reliable animal models of type 2 diabetes are required. Physiologically relevant rodent models are needed, which not only replicate the human pathology but also mimic the disease process. Here we characterised cardiac metabolic abnormalities, and investigated the optimal experimental approach for inducing disease, in a new model of type 2 diabetes....
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