Article
Left ventricular radial function associated with genetic variation in the cGMP-dependent protein kinase.
Hypertension (Dallas, Tex. : 1979) - 1 Dec 2013
Kuznetsova Tatiana, Citterio Lorena, Zagato Laura, Delli Carpini Simona, Thijs Lutgarde, Casamassima Nunzia, D'hooge Jan, Bianchi Giuseppe, Manunta Paolo, Staessen Jan A
Abstract excerpt
cGMP-dependent protein kinase type I is a major mediator of cGMP signaling in the cardiovascular system. Recent studies on cardiac-specific PRKG1 knockout mice demonstrated that cGMP-dependent protein kinase type I mediates the negative inotropic effect of cGMP in the myocardium. We therefore investigated the association between left ventricular (LV) function and common polymorphisms in the PRKG1 gene in a...
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