Article
Association and interaction of PPAR-complex gene variants with latent traits of left ventricular diastolic function.
BMC medical genetics - 28 Apr 2010
Juang Jyh-Ming Jimmy, de las Fuentes Lisa, Waggoner Alan D, Gu C Charles, Dávila-Román Víctor G
Abstract excerpt
BACKGROUND: Abnormalities in myocardial metabolism and/or regulatory genes have been implicated in left ventricular systolic dysfunction. However, the extent to which these modulate left ventricular diastolic function (LVDF) is uncertain. METHODS: Independent component analysis was applied to extract latent LVDF traits from 14 measured echocardiography-derived endophenotypes of LVDF in 403 Caucasians. Genetic...
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