Article
Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects.
Circulation. Genomic and precision medicine - 1 Mar 2018
Hu Ray, Morley Michael P, Brandimarto Jeffrey, Tucker Nathan R, Parsons Victoria A, Zhao Sihai D, Meder Benjamin, Katus Hugo A, Rühle Frank, Stoll Monika, Villard Eric, Cambien François, Lin Honghuang, Smith Nicholas L, Felix Janine F, Vasan Ramachandran S, van der Harst Pim, Newton-Cheh Christopher, Li Jin, Kim Cecilia E, Hakonarson Hakon, Hannenhalli Sridhar, Ashley Euan A, Moravec Christine S, Tang W H Wilson, Maillet Marjorie, Molkentin Jeffery D, Ellinor Patrick T, Margulies Kenneth B, Cappola Thomas P
Abstract excerpt
BACKGROUND: Inhibition of PKC-α (protein kinase C-α) enhances contractility and cardioprotection in animal models, but effects in humans are unknown. Genotypes at rs9912468 strongly associate with PRKCA expression in the left ventricle, enabling genetic approaches to measure effects of reduced PKC-α in human populations. METHODS AND RESULTS: We analyzed the cis expression quantitative trait locus for PRKCA marked...
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