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Article

A powerful latent variable method for detecting and characterizing gene-based gene-gene interaction on multiple quantitative traits.

BMC genetics - 23 Sept 2013

Li Fangyu, Zhao Jinghua, Yuan Zhongshang, Zhang Xiaoshuai, Ji Jiadong, Xue Fuzhong

Abstract excerpt

BACKGROUND: On thinking quantitatively of complex diseases, there are at least three statistical strategies for analyzing the gene-gene interaction: SNP by SNP interaction on single trait, gene-gene (each can involve multiple SNPs) interaction on single trait and gene-gene interaction on multiple traits. The third one is the most general in dissecting the genetic mechanism underlying complex diseases underpinning...

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PMID: 24059907
DOI: 10.1186/1471-2156-14-89
PMCID: PMC3848962

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