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Article

Mitochondrial DNA Damage and Its Repair Mechanisms in Aging Oocytes.

International journal of molecular sciences - 6 Dec 2024

Kobayashi Hiroshi, Imanaka Shogo

Abstract excerpt

The efficacy of assisted reproductive technologies (ARTs) in older women remains constrained, largely due to an incomplete understanding of the underlying pathophysiology. This review aims to consolidate the current knowledge on age-associated mitochondrial alterations and their implications for ovarian aging, with an emphasis on the causes of mitochondrial DNA (mtDNA) mutations, their repair mechanisms, and...

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Aging
DNA Damage
DNA, Mitochondrial
DNA Repair
Mitochondria
Oocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Reactive Oxygen Species

Reproductive Techniques, Assisted

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Identifiers

PMID: 39684855
DOI: 10.3390/ijms252313144
PMCID: PMC11642581

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