Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In silico explanation for the causalities of deleterious RNF213 SNPs in Moyamoya disease and insulin resistance.

Computational biology and chemistry - 1 Jun 2021

Sarkar Priyanka, Thirumurugan Kavitha

Abstract excerpt

Moyamoya disease (MMD), a cerebrovascular disorder caused by the RNF213 gene, is a cerebrovascular, neurological disorder leading to ischemic strokes. Our previous work suggested that RNF213 might be involved in the pro-inflammatory TNFα-mediated insulin-resistance pathway in adipocytes. Insulin resistance can lead to cerebrovascular diseases and ischemic strokes. Though p. R4810 K has been reported as the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Insulin Resistance
Share to Moyamoya Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Ubiquitin-Protein Ligases

Source

Identifiers

PMID: 33930741
DOI: 10.1016/j.compbiolchem.2021.107488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In silico explanation for the causalities of deleterious RNF213 SNPs in Moyamoya disease and insulin resistance.PMID 33930741Read ↗

New insights into TNFα/PTP1B and PPARγ pathway through RNF213- a link between inflammation, obesity, insulin resistance and Moyamoya diseaseSemantic proximity Read ↗

RNF213 in moyamoya disease: Genotype-phenotype association and the underlying mechanism.Semantic proximity Read ↗

Difference in Clinical Phenotype, Mutation Position, and Structural Change of RNF213 Rare Variants Between Pediatric and Adult Japanese Patients with Moyamoya Disease.Semantic proximity Read ↗

Novel Multifaceted Roles for RNF213 Protein.Semantic proximity Read ↗

Meta-analysis of genotype and phenotype studies to confirm the predictive role of the RNF213 p.R4810K variant for moyamoya disease.Semantic proximity Read ↗

RNF213-Related Vasculopathy: Various Systemic Vascular Diseases Involving RNF213 Gene Mutations: Review.Semantic proximity Read ↗

The Association of the RNF213 p.R4810K Polymorphism with Quasi-Moyamoya Disease and a Review of the Pertinent Literature.Semantic proximity Read ↗

Validation and Extension Study Exploring the Role of RNF213 p.R4810K in 2,877 Chinese Moyamoya Disease Patients.Semantic proximity Read ↗

Frequency and significance of rare RNF213 variants in patients with adult moyamoya disease.Semantic proximity Read ↗

Rare variants of RNF213 and moyamoya/non-moyamoya intracranial artery stenosis/occlusion disease risk: a meta-analysis and systematic review.Semantic proximity Read ↗

Moyamoya Disease and Spectrums of RNF213 Vasculopathy.Semantic proximity Read ↗

Familial Moyamoya disease associated with dual RNF213 variants (R4810K and T1727M): A case report and genetic investigation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.