Article
Resequencing of Treponema pallidum ssp. pallidum strains Nichols and SS14: correction of sequencing errors resulted in increased separation of syphilis treponeme subclusters.
PloS one - 1 Jan 2013
Pětrošová Helena, Pospíšilová Petra, Strouhal Michal, Čejková Darina, Zobaníková Marie, Mikalová Lenka, Sodergren Erica, Weinstock George M, Šmajs David
Abstract excerpt
BACKGROUND: Treponema pallidum ssp. pallidum (TPA), the causative agent of syphilis, is a highly clonal bacterium showing minimal genetic variability in the genome sequence of individual strains. Nevertheless, genetically characterized syphilis strains can be clearly divided into two groups, Nichols-like strains and SS14-like strains. TPA Nichols and SS14 strains were completely sequenced in 1998 and 2008,...
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