Article
Next-generation mapping of genetic mutations using bulk population sequencing.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014
Austin Ryan S, Chatfield Steven P, Desveaux Darrell, Guttman David S
Abstract excerpt
Next-generation sequencing platforms have made it possible to very rapidly map genetic mutations in Arabidopsis using whole-genome resequencing against pooled members of an F2 mapping population. In the case of recessive mutations, all individuals expressing the phenotype will be homozygous for the mutant genome at the locus responsible for the phenotype, while all other loci segregate roughly equally for both...
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