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Article

Genotypic stability of cold-adapted influenza virus vaccine in an efficacy clinical trial.

Journal of clinical microbiology - 1 Feb 2000

Cha T A, Kao K, Zhao J, Fast P E, Mendelman P M, Arvin A

Abstract excerpt

An investigational live influenza virus vaccine, FluMist, contains three cold-adapted H1N1, H3N2, and B influenza viruses. The vaccine viruses are 6/2 reassortants, in which the hemagglutinin (HA) and neuraminidase (NA) genes are derived from the circulating wild-type viruses and the remaining six genes are derived from the cold-adapted master donor strains. The six genes from the cold-adapted master donor...

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Identifiers

PMID: 10655394
DOI: 10.1128/JCM.38.2.839-845.2000
PMCID: PMC86217

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Source receipt: pubmed, retrieved 7 Sept 2026.

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