Article
Photobiological effects in Saccharomyces cerevisiae induced by the monofunctional furocoumarin 4,4',6-trimethylangelicin (TMA) and the bifunctional furocoumarin 8-methoxypsoralen (8-MOP).
Mutation research - 1 Jan 1990
Bianchi L, Bianchi A, Dall'Acqua F, Santamaria L
Abstract excerpt
Recently, the monofunctional furocoumarin 4,4',6-trimethylangelicin (TMA) has been proposed for photochemotherapeutic use. In order to assess its genotoxic potential, the photobiological (genetic) effects of TMA were studied in a diploid strain of Saccharomyces cerevisiae (D7) and compared to those of the bifunctional furocoumarin 8-methoxypsoralen (8-MOP). At equimolar concentrations, the induction of lethal...
Topics
- Cell Survival
- Crossing Over, Genetic
- Furocoumarins
- Genes, Fungal
- Methoxsalen
- Mitosis
- Mutagens
- Mutation
- Photochemotherapy
- Saccharomyces cerevisiae