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Article

Photochemotherapy using pyridopsoralens.

Biochimie - 1 Jan 2000

Dubertret L, Averbeck D, Bisagni E, Moron J, Moustacchi E, Billardon C, Papadopoulo D, Nocentini S, Vigny P, Blais J

Abstract excerpt

Aiming to decrease the acute side effects and genotoxic hazards of PUVA, pyrido (3,4-C) psoralen (PP) and 7-methyl pyrido (3,4-C) psoralen (MPP) were synthesized and studied. Their UVA maximum absorption lies at 325 and 330 nm, respectively. Their photostability is comparable to that of 8-MOP. They complex to DNA in the dark, and, in the presence of UVA, produce only monoadditions to DNA, as shown by fluorescence...

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PMID: 3899194
DOI: 10.1016/s0300-9084(85)80090-0

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