Genotoxic activity of 4,4',5'-trimethylazapsoralen on plasmid DNA.

Article

Genotoxic activity of 4,4',5'-trimethylazapsoralen on plasmid DNA.

Teratogenesis, carcinogenesis, and mutagenesis - 1 Jan 1998

Lagatolla C, Dolzani L, Granzotto M, Monti-Bragadin C

Abstract excerpt

The genotoxic activities of 8-methoxypsoralen (8-MOP) and 4,4',5'-trimethylazapsoralen (4,4',5'-TMAP) on plasmid DNA have been compared. In a previous work, 4,4',5'-TMAP, a methyl derivative of a psoralen isoster, had shown potential photochemotherapeutic activity. The mutagenic activity of mono-...

Topics

DNA
Furocoumarins
Methoxsalen
Mutation
Plasmids
Ultraviolet Rays

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