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Article

Isolation and characterization of three mutants with increased sensitivity to photoactivated 3-carbethoxypsoralen in Saccharomyces cerevisiae.

Current genetics - 1 May 1994

Querol C B, Paesi-Toresan S O, Meira L B, Brendel M, Henriques J A

Abstract excerpt

The complementation and genetical analysis of yeast mutants sensitive to photoactivated 3-carbethoxypsoralen define three novel recessive mutant alleles pso5-1, pso6-1, and pso7-1. Their cross-sensitivity to UV254nm, radiomimetic mutagens, and to chemicals enhancing oxidative stress suggest that...

Topics

DNA Damage
DNA Repair
Drug Resistance, Microbial
Furocoumarins
Genetic Complementation Test
Haploidy
Mutation
Oxidation-Reduction
Photochemistry
Saccharomyces cerevisiae
Ultraviolet Rays

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PMID: 8082185
DOI: 10.1007/BF00351778

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8082185-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Isolation and characterization of three mutants with increased sensitivity to photoactivated 3-carbethoxypsoralen in Saccharomyces cerevisiae.PMID 8082185Read ↗

Mutant pso8-1 of Saccharomyces cerevisiae, sensitive to photoactivated psoralens, UV radiation, and chemical mutagens, contains a rad6 missense mutant allele.Semantic proximity Read ↗

The pso mutants of Saccharomyces cerevisiae comprise two groups: one deficient in DNA repair and another with altered mutagen metabolism.Semantic proximity Read ↗

Lethal and mutagenic effects photoinduced in haploid yeast (Saccharomyces cerevisiae) by two new monofunctional pyridopsoralens compared to 3-carbethoxypsoralen and 8-methoxypsoralen.Semantic proximity Read ↗

Further phenotypic characterization of pso mutants of Saccharomyces cerevisiae with respect to DNA repair and response to oxidative stress.Semantic proximity Read ↗

The DNA repair gene PSO3 of Saccharomyces cerevisiae belongs to the RAD3 epistasis group.Semantic proximity Read ↗

Psoralen-sensitive mutant pso9-1 of Saccharomyces cerevisiae contains a mutant allele of the DNA damage checkpoint gene MEC3.Semantic proximity Read ↗

Allelism of Saccharomyces cerevisiae genes PSO6, involved in survival after 3-CPs+UVA induced damage, and ERG3, encoding the enzyme sterol C-5 desaturase.Semantic proximity Read ↗

Mutant allele pso7-1, that sensitizes Saccharomyces cerevisiae to photoactivated psoralen, is allelic with COX11, encoding a protein indispensable for a functional cytochrome c oxidase.Semantic proximity Read ↗

Allelism of Saccharomyces cerevisiae gene PSO10, involved in error-prone repair of psoralen-induced DNA damage, with SUMO ligase-encoding MMS21.Semantic proximity Read ↗

Photobiological effects in Saccharomyces cerevisiae induced by the monofunctional furocoumarin 4,4',6-trimethylangelicin (TMA) and the bifunctional furocoumarin 8-methoxypsoralen (8-MOP).Semantic proximity Read ↗

Low glutathione pools in the original pso3 mutant of Saccharomyces cerevisiae are responsible for its pleiotropic sensitivity phenotype.Semantic proximity Read ↗

Further characterisation of processes removing EMS premutational lesions in yeast (S. cerevisiae).Semantic proximity Read ↗

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