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Article

Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage

14 Nov 2016

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron dysfunction disease that leads to paralysis and death. There is currently no established molecular pathogenesis pathway. Multiple proteins involved in RNA processing are linked to ALS, including FUS and TDP43, and we propose a disease mechanism in which loss of function of at least one of these proteins leads to an accumulation of...

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PMID: 27849576
DOI: 10.1073/pnas.1611673113

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