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Article

Detection of cytochrome P450 2C19 gene polymorphism from noninvasive samples by cycling probe technology.

Annals of clinical biochemistry - 1 Mar 2014

Nakagawa Saori, Kuwabara Naoko, Takamatsu Yu, Shimoeda Sadahiko, Ohta Shin, Yamato Susumu

Abstract excerpt

BACKGROUND: The proportion of poor metabolizers (PMs) of cytochrome P450 (CYP) 2C19 is much higher in the Japanese population than in European populations. Cycling probe technology (CPT) is a simple signal amplification technique for targeting specific DNA sequences. CPT utilizes a chimeric DNA-RNA-DNA probe that is cleaved by the enzyme ribonuclease (RNase H). In this study, using CPT, we aimed to detect the...

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PMID: 24048716
DOI: 10.1177/0004563213499316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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