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Article

Western blotting analysis for quantitative detection of CYP2C19 expression in liver tissues in the setting of living donor liver transplantation.

Hepato-gastroenterology - 1 May 2012

Chiu King-Wah, Nakano Toshiaki, Tseng Hui-Peng, Cheng Yu-Fan, Jawan Bruno, Eng Hock-Liew, Goto Shigeru, Chen Chao-Long

Abstract excerpt

BACKGROUND: The cytochrome P450 (CYP) drug-metabolizing enzymes play an important role in cellular metabolism. Therapeutic failure or drug toxicity in the period after liver transplantation (LT) is influenced by the drug metabolizing capacity of the graft. The expression levels of CYP2C19 enzyme are often used as an indicator of the functioning of the CYP system. The aim of the present study was to assess the...

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PMID: 22469723
DOI: 10.5754/hge09722

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