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Article

Whole genome sequence analysis of serum amino acid levels.

Genome biology - 24 Nov 2016

Yu Bing, de Vries Paul S, Metcalf Ginger A, Wang Zhe, Feofanova Elena V, Liu Xiaoming, Muzny Donna Marie, Wagenknecht Lynne E, Gibbs Richard A, Morrison Alanna C, Boerwinkle Eric

Abstract excerpt

BACKGROUND: Blood levels of amino acids are important biomarkers of disease and are influenced by synthesis, protein degradation, and gene-environment interactions. Whole genome sequence analysis of amino acid levels may establish a paradigm for analyzing quantitative risk factors. RESULTS: In a discovery cohort of 1872 African Americans and a replication cohort of 1552 European Americans we sequenced exons and...

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PMID: 27884205
DOI: 10.1186/s13059-016-1106-x
PMCID: PMC5123402

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