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Article

Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing.

PloS one - 1 Jan 2012

Liu Ting, Zhao Yanxia, Tang Na, Feng Ruopeng, Yang Xiaolong, Lu Nicole, Wen Jinhua, Li Lingsong

Abstract excerpt

BACKGROUND: Heterozygous paired box6 (Pax6) mutations lead to abnormal glucose metabolism in mice older than 6 months as well as in human beings. Our previous study found that Pax6 deficiency caused down-expression of prohormone convertase 1/3 (Pcsk1), resulting in defective proinsulin processing...

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Identifiers

PMID: 23056534
DOI: 10.1371/journal.pone.0046934
PMCID: PMC3467282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23056534-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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