Article
PAX6 is expressed in pancreatic cancer and actively participates in cancer progression through activation of the MET tyrosine kinase receptor gene.
The Journal of biological chemistry - 2 Oct 2009
Mascarenhas Joseph B, Young Kacey P, Littlejohn Erica L, Yoo Brian K, Salgia Ravi, Lang Deborah
Abstract excerpt
Tumors of the exocrine pancreas have a poor prognosis. Several proteins are overexpressed in this cancer type, including the MET tyrosine kinase receptor and the transcription factor PAX6. In this report, we find that PAX6(5a), an alternately spliced variant form of PAX6, is expressed in pancreatic carcinoma cell lines at higher levels than the canonical PAX6 protein. Both protein forms of PAX6 bind directly to...
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