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Article

Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells.

Stem cell research - 1 Nov 2013

Jonson Ida, Ougland Rune, Klungland Arne, Larsen Elisabeth

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded trinucleotide CAG repeat in the Huntingtin (Htt) gene. The molecular basis for the development and progression of HD is currently poorly understood. However, different DNA repair pathways have been implicated in both somatic expansion and disease progression. Embryonic stem cells provide a remarkable in vitro system to study HD and...

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Identifiers

PMID: 24041806
DOI: 10.1016/j.scr.2013.08.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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