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Article

Critical role of host γδ T cells in experimental acute graft-versus-host disease

30 Mar 2005

Abstract excerpt

Gammadelta T cells localize to target tissues of graft-versus-host disease (GVHD) and therefore we investigated the role of host gammadelta T cells in the pathogenesis of acute GVHD in several well-characterized allogeneic bone marrow transplantation (BMT) models. Depletion of host gammadelta T cells in wild-type (wt) B6 recipients by administration of anti-T-cell receptor (TCR) gammadelta monoclonal antibody...

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PMID: 15797996
DOI: 10.1182/blood-2004-10-4087

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