Article
The role of eight polymorphisms in three candidate genes in determining the susceptibility, phenotype, and response to anti-TNF therapy in patients with rheumatoid arthritis.
Clinical and experimental rheumatology - 1 Jan 2000
Ceccarelli Fulvia, D'Alfonso Sandra, Perricone Carlo, Carlomagno Yari, Alessandri Cristiano, Croia Cristina, Barizzone Nadia, Montecucco Carlomaurizio, Galeazzi Mauro, Sebastiani Gian Domenico, Minisola Giovanni, Fiocco Ugo, Valesini Guido
Abstract excerpt
OBJECTIVES: Several single nucleotide polymorphisms (SNPs) have been associated with rheumatoid arthritis (RA) such as peptidylarginine deiminase-4 (PADI4), osteopontin (OPN), and perforin (PRF1) genes. Thus, we aimed at analysing the influence of eight SNPs in these candidate genes on RA susceptibility and their association with laboratory and clinical features in terms of response to anti-TNF therapy. METHODS:...
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