Article
Expression of HLA-DR antigens at the surface of mouse L cells co-transfected with cloned human genes.
Nature - 1 Jan 2000
Rabourdin-Combe C, Mach B
Abstract excerpt
The H-2 I region in the mouse and the HLA-D region in humans contain a set of polymorphic genes which encode Ia antigens and control the immune response. Cloned genes for the different polypeptide chains of one of the human Ia antigens, HLA-DR, have been used for the co-transformation of mouse L...
Topics
- Animals
- Cloning, Molecular
- DNA Restriction Enzymes
- Fluorescent Antibody Technique
- Genes
- Genes, MHC Class II
- HLA-DR Antigens
- Humans
- L Cells
- Major Histocompatibility Complex
- Mice
- Mutation
- Nucleic Acid Hybridization