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Article

Cholesterol lowering drug may influence cellular immune response by altering MHC II function.

Journal of lipid research - 1 Nov 2013

Roy Koushik, Ghosh Moumita, Pal Tuhin Kumar, Chakrabarti Saikat, Roy Syamal

Abstract excerpt

Major histocompatibility complex class II (MHC II) expressed on the surface of antigen-presenting cells (APCs) displays peptides to CD4⁺ T cells. Depletion of membrane cholesterol from APCs by methyl β-cyclodextrin treatment compromises peptide-MHC II complex formation coupled with impaired binding of conformational antibody, which binds close to the peptide binding groove of MHC II. Interestingly, the total cell...

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Identifiers

PMID: 24038316
DOI: 10.1194/jlr.M041954
PMCID: PMC3793615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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