Article
The presence of prostate cancer at biopsy is predicted by a number of genetic variants.
International journal of cancer - 1 Mar 2014
Kashyap Aniruddh, Kluźniak Wojciech, Wokołorczyk Dominika, Gołąb Adam, Sikorski Andrzej, Słojewski Marcin, Gliniewicz Bartłomiej, Świtała Jerzy, Borkowski Tomasz, Borkowski Andrzej, Antczak Andrzej, Wojnar Łukasz, Przybyła Jacek, Sosnowski Marek, Małkiewicz Bartosz, Zdrojowy Romuald, Sikorska-Radek Paulina, Matych Józef, Wilkosz Jacek, Różański Waldemar, Kiś Jacek, Bar Krzysztof, Bryniarski Piotr, Paradysz Andrzej, Jersak Konrad, Niemirowicz Jerzy, Słupski Piotr, Jarzemski Piotr, Skrzypczyk Michał, Dobruch Jakub, Domagała Paweł, Piotrowski Krzysztof, Jakubowska Anna, Gronwald Jacek, Huzarski Tomasz, Byrski Tomasz, Dębniak Tadeusz, Górski Bohdan, Masojć Bartłomiej, van de Wetering Thierry, Menkiszak Janusz, Akbari Mohammad R, Lubiński Jan, Narod Steven A, Cybulski Cezary
Abstract excerpt
Several single nucleotide polymorphisms (SNPs) have been associated with an elevated risk of prostate cancer risk. It is not established if they are useful in predicting the presence of prostate cancer at biopsy or if they can be used to define a low-risk group of men. In this study, 4,548 men underwent a prostate biopsy because of an elevated prostate specific antigen (PSA; ≥4 ng/mL) or an abnormal digital...
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