Article
Genetic correction of PSA values using sequence variants associated with PSA levels.
Science translational medicine - 15 Dec 2010
Gudmundsson Julius, Besenbacher Soren, Sulem Patrick, Gudbjartsson Daniel F, Olafsson Isleifur, Arinbjarnarson Sturla, Agnarsson Bjarni A, Benediktsdottir Kristrun R, Isaksson Helgi J, Kostic Jelena P, Gudjonsson Sigurjon A, Stacey Simon N, Gylfason Arnaldur, Sigurdsson Asgeir, Holm Hilma, Bjornsdottir Unnur S, Eyjolfsson Gudmundur I, Navarrete Sebastian, Fuertes Fernando, Garcia-Prats Maria D, Polo Eduardo, Checherita Ionel A, Jinga Mariana, Badea Paula, Aben Katja K, Schalken Jack A, van Oort Inge M, Sweep Fred C, Helfand Brian T, Davis Michael, Donovan Jenny L, Hamdy Freddie C, Kristjansson Kristleifur, Gulcher Jeffrey R, Masson Gisli, Kong Augustine, Catalona William J, Mayordomo Jose I, Geirsson Gudmundur, Einarsson Gudmundur V, Barkardottir Rosa B, Jonsson Eirikur, Jinga Viorel, Mates Dana, Kiemeney Lambertus A, Neal David E, Thorsteinsdottir Unnur, Rafnar Thorunn, Stefansson Kari
Abstract excerpt
Measuring serum levels of the prostate-specific antigen (PSA) is the most common screening method for prostate cancer. However, PSA levels are affected by a number of factors apart from neoplasia. Notably, around 40% of the variability of PSA levels in the general population is accounted for by i...
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