Article
NF-kappaB-dependent transcriptional regulation of the cardiac scn5a sodium channel by angiotensin II.
American journal of physiology. Cell physiology - 1 Jan 2008
Shang Lijuan L, Sanyal Shamarendra, Pfahnl Arnold E, Jiao Zhe, Allen Jon, Liu Hong, Dudley Samuel C
Abstract excerpt
Angiotensin II (ANG II) increases oxidative stress and is associated with increased risk of sudden cardiac death. The cardiac Na(+) channel promoter contains elements that confer redox sensitivity. We tested the hypothesis that ANG II-mediated oxidative stress may modulate Na(+) channel current through altering channel transcription. In H9c2 myocytes treated for 48 h with ANG II (100 nmol/l) or H(2)O(2) (10...
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