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Article

Characterization of a prothrombotic phenotype using thrombin generation and thrombin activity in cirrhosis and portal hypertension.

Thrombosis research - 1 Feb 2023

Königsbrügge Oliver, Scheiner Bernhard, Simbrunner Benedikt, Semmler Georg, Quehenberger Peter, Pabinger-Fasching Ingrid, Trauner Michael, Mandorfer Mattias, Lisman Ton, Ay Cihan, Reiberger Thomas

Abstract excerpt

BACKGROUND: Patients with advanced chronic liver disease (ACLD) may develop a prothrombotic phenotype that seems to be more pronounced with more severe liver dysfunction. An imbalance of endogenous pro- and anticoagulants is not fully captured by routine coagulation assays. METHODS: In a cohort of ACLD patients undergoing hepatic venous pressure gradient (HVPG) measurement, we assessed thrombin generation (TGA)...

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Identifiers

PMID: 36646026
DOI: 10.1016/j.thromres.2023.01.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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