Article
Seizure predisposition after perinatal hypoxia: effects of subsequent age and of an epilepsy predisposing gene mutation.
Epilepsia - 1 Oct 2013
Leonard A Soren, Hyder S Nabeel, Kolls Brad J, Arehart Eric, Ng Kim C W, Veerapandiyan Aravindhan, Mikati Mohamad A
Abstract excerpt
PURPOSE: There is a gap in our knowledge of the factors that modulate the predisposition to seizures following perinatal hypoxia. Herein, we investigate in a mouse model the effects of two distinct factors: developmental stage after the occurrence of the perinatal insult, and the presence of a seizure predisposing mutation. METHODS: Effects of age: P6 (postnatal day 6) mouse pups were subjected to acute hypoxia...
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