Article
Electroconvulsive seizure thresholds and kindling acquisition rates are altered in mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions.
Epilepsia - 1 Jul 2009
Otto James F, Singh Nanda A, Dahle E Jill, Leppert Mark F, Pappas Chris M, Pruess Timothy H, Wilcox Karen S, White H Steve
Abstract excerpt
PURPOSE: Benign familial neonatal convulsions (BFNC) is caused by mutations in the KCNQ2 and KCNQ3 genes, which encode subunits of the M-type potassium channel. The purpose of this study was to examine the effects of orthologous BFNC-causing mutations on seizure thresholds and the acquisition of corneal kindling in mice with heterozygous expression of the mutations. METHODS: The effects of the Kcnq2 gene A306T...
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