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Article

Passive Smoking Impairs Histone Deacetylase-2 in Children With Severe Asthma

12 Sept 2013

Abstract excerpt

BACKGROUND: Parental smoking is known to worsen asthma symptoms in children and to make them refractory to asthma treatment, but the molecular mechanism is unclear. Oxidative stress from tobacco smoke has been reported to impair histone deacetylase-2 (HDAC2) via phosphoinositide-3-kinase (PI3K)/Akt activation and, thus, to reduce corticosteroid sensitivity. The aim of this study was to investigate passive...

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PMID: 24030221
DOI: 10.1378/chest.13-0835

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