Article

HDAC8-Selective Inhibition by PCI-34051 Attenuates Inflammation and Airway Remodeling in Asthma via miR-381-3p-TGFβ3 axis

2023-02-14

Abstract excerpt

<h4>Background: </h4> Histone deacetylase (HDAC) families regulate a wide range of physical processes and development of several diseases, and the role of HDACs in asthma development and progression is worth further investigation. This study aimed to evaluate HDAC effects in a mouse model of asthma. <h4>Methods: </h4>: HDAC8 selective inhibitor PCI-34051 was administered to a mouse model of ovalbumin (OVA)-sensit...

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Literature Corpus work: 86364e2f-7033-532d-ba5b-080a37c4a7cb
DOI: 10.21203/rs.3.rs-2573090/v1

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